5,006 research outputs found
A model to assess customer alignment through customer experience concepts
Business and Information Technology Alignment (BITA) has been one of the main
concerns of IT and Business executives and directors due to its importance to
overall company performance, especially today in the age of digital
transformation. For BITA has been developed several models which in general has
focused in the implementation of alignment strategies for the internal
operation of the organizations and in the measurement of this internal
alignment, but, there is still a big gap in measurement models of the alignment
with the external environment of the organizations. In this paper is presented
the design and application of a maturity measurement model for BITA with the
customers, where the customers are actors of the external environment of the
companies. The proposed model involves evaluation criteria and business
practices which the companies ideally do for improve the relationship with
their customers.Comment: 12 pages, Preprint version, BIS 2019 International Workshops,
Seville, Spain, June 26 to 28, 2019, Revised Paper
An experience in modelling business process architecture
We present a mapping of a previously designed Business Process
Architecture (BPA) meta-model onto ArchiMate, i.e., the de facto standard
Enterprise Architecture (EA) modelling language. This construct mapping allows
developing process maps, i.e., descriptions of (views of) the business process
architecture of an organization. We demonstrate the development of these process maps using the Signavio Business Process Management (BPM) modelling
platform. The developed process maps are part of the organizationâs enterprise
architecture model and are linked to BPMN process diagrams that detail the
functional, control-flow, data and resource aspects of the business processes
included in the process map. Our research contributes to the integration of BPM
and EA by researching BPA as a concept common to both disciplines
Conservative management of grade 1V renal injury with complete transection: a case report
The expectant management of high grade renal injuries in hemodynamically stable children has gained increasing acceptance amongst paediatric surgeons. However, patients with grade 1V injury with complete renal transection have been identified as a subgroup with a poor outcome that may benefit from early operative intervention
Business and Information Technology Alignment Measurement -- a recent Literature Review
Since technology has been involved in the business context, Business and
Information Technology Alignment (BITA) has been one of the main concerns of IT
and Business executives and directors due to its importance to overall company
performance, especially today in the age of digital transformation. Several
models and frameworks have been developed for BITA implementation and for
measuring their level of success, each one with a different approach to this
desired state. The BITA measurement is one of the main decision-making tools in
the strategic domain of companies. In general, the classical-internal alignment
is the most measured domain and the external environment evolution alignment is
the least measured. This literature review aims to characterize and analyze
current research on BITA measurement with a comprehensive view of the works
published over the last 15 years to identify potential gaps and future areas of
research in the field.Comment: 12 pages, Preprint version, BIS 2018 International Workshops, Berlin,
Germany, July 18 to 20, 2018, Revised Paper
Saddle point localization of molecular wavefunctions
The quantum mechanical description of isomerization is based on bound eigenstates of the molecular potential energy surface. For the near-minimum regions there is a textbook-based relationship between the potential and eigenenergies. Here we show how the saddle point region that connects the two minima is encoded in the eigenstates of the model quartic potential and in the energy levels of the [H, C, N] potential energy surface. We model the spacing of the eigenenergies with the energy dependent classical oscillation frequency decreasing to zero at the saddle point. The eigenstates with the smallest spacing are localized at the saddle point. The analysis of the HCN???HNC isomerization states shows that the eigenstates with small energy spacing relative to the effective (v1, v3, l) bending potentials are highly localized in the bending coordinate at the transition state. These spectroscopically detectable states represent a chemical marker of the transition state in the eigenenergy spectrum. The method developed here provides a basis for modeling characteristic patterns in the eigenenergy spectrum of bound states
Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) use may protect against Alzheimer's disease (AD) risk. We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-Δ4 carrier status and ethnicity. METHODS: The MIRAGE Study is a multi-center family study of genetic and environmental risk factors for AD. Subjects comprised 691 AD patients (probands) and 973 family members enrolled at 15 research centers between 1996 and 2002. The primary independent and dependent variables were prior NSAID use and AD case status, respectively. We stratified the dataset in order to evaluate whether the association between NSAID use and AD was similar in APOE-Δ4 carriers and non-carriers. Ethnicity was similarly examined as an effect modifier. RESULTS: NSAID use was less frequent in cases compared to controls in the overall sample (adjusted OR = 0.64; 95% CI = 0.38â1.05). The benefit of NSAID use appeared more pronounced among APOE-Δ4 carriers (adjusted OR = 0.49; 95% CI = 0.24â0.98) compared to non-carriers, although this association was not statistically significant. The pattern of association was similar in Caucasian and African Americans. CONCLUSIONS: NSAID use is inversely associated with AD and may be modified by APOE genotype. Prospective studies and clinical trials of sufficient power to detect effect modification by APOE-Δ4 carrier status are needed
Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast
Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs). The timing of DSB formation is strictly controlled because unscheduled DSB formation is detrimental to genome integrity. Here, we investigated the role of DNA damage checkpoint mechanisms in the control of meiotic DSB formation using budding yeast. By using recombination defective mutants in which meiotic DSBs are not repaired, the effect of DNA damage checkpoint mutations on DSB formation was evaluated. The Tel1 (ATM) pathway mainly responds to unresected DSB ends, thus the sae2 mutant background in which DSB ends remain intact was employed. On the other hand, the Mec1 (ATR) pathway is primarily used when DSB ends are resected, thus the rad51 dmc1 double mutant background was employed in which highly resected DSBs accumulate. In order to separate the effect caused by unscheduled cell cycle progression, which is often associated with DNA damage checkpoint defects, we also employed the ndt80 mutation which permanently arrests the meiotic cell cycle at prophase I. In the absence of Tel1, DSB formation was reduced in larger chromosomes (IV, VII, II and XI) whereas no significant reduction was found in smaller chromosomes (III and VI). On the other hand, the absence of Rad17 (a critical component of the ATR pathway) lead to an increase in DSB formation (chromosomes VII and II were tested). We propose that, within prophase I, the Tel1 pathway facilitates DSB formation, especially in bigger chromosomes, while the Mec1 pathway negatively regulates DSB formation. We also identified prophase I exit, which is under the control of the DNA damage checkpoint machinery, to be a critical event associated with down-regulating meiotic DSB formation
Measuring every particle's size from three-dimensional imaging experiments
Often experimentalists study colloidal suspensions that are nominally
monodisperse. In reality these samples have a polydispersity of 4-10%. At the
level of an individual particle, the consequences of this polydispersity are
unknown as it is difficult to measure an individual particle size from
microscopy. We propose a general method to estimate individual particle radii
within a moderately concentrated colloidal suspension observed with confocal
microscopy. We confirm the validity of our method by numerical simulations of
four major systems: random close packing, colloidal gels, nominally
monodisperse dense samples, and nominally binary dense samples. We then apply
our method to experimental data, and demonstrate the utility of this method
with results from four case studies. In the first, we demonstrate that we can
recover the full particle size distribution {\it in situ}. In the second, we
show that accounting for particle size leads to more accurate structural
information in a random close packed sample. In the third, we show that crystal
nucleation occurs in locally monodisperse regions. In the fourth, we show that
particle mobility in a dense sample is correlated to the local volume fraction.Comment: 7 pages, 5 figure
Digital Transformation Business Landscape
Chapter 3 is based on an approach to the background and basic understanding of digital transformation; its benefits, the two perspectives of digital transformation, the four dimensions of digital transformation strategies and the procedural aspects of digital transformation strategies are discussed.
Following that, there is an explanation on how to integrate digital transformation into firms and some challenges and strategic paths in order to do this effectively.2019-2
- âŠ